How is the heart valve formed at the atrioventricular valve opening?Ca2 + signal due to shear stress plays an important role

Tetsushi Furukawa's "Bridge between Basics and Clinical"

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There are two types of mechanical forces acting on the cardiovascular system: shear stress and stretching force. Mechanical forces are transmitted to cardiac endothelial cells by a pathway called the "mechano-transduction" and are thought to be involved in the formation of heart valves, but the detailed molecular mechanism has been fully elucidated. Not. For example, although mechanical forces are applied to the entire cardiac endothelium, the mechanism by which the heart valve is formed only in the atrioventricular valve ( AVC ) region is unknown. Recently, groups such as the National Cardiovascular Research Center have clarified this mechanism in experiments using zebrafish and published it in Science.

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Tetsushi Furukawa (Professor, Department of Bioinformatics and Pharmacology, Institute for Intractable Diseases, Tokyo Medical and Dental University) Mr. Tetsushi Furukawa. Completed the doctoral course at the Graduate School of Medicine, Tokyo Medical & Dental University in 1989. After studying abroad at the Miami Heart Institute in the United States and the University of Miami, he was an assistant in the field of autonomous physiology at the Institute for Intractable Diseases, Tokyo Medical and Dental University in 1994. He was an assistant professor at the First Physiology Department, Akita University School of Medicine in 1999, and has been in his current position since April 2003.

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Tetsushi Furukawa's "Bridge between Basics and Clinical Practice" Tetsushi Furukawa, who turned from a clinician to research on basic medicine, should know the basic knowledge that he should know in order to practice a higher-grade clinical practice. Ask the material to unravel.

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